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Out now: a new model for metastatic cancer

Our collaborative study just published in Clinical & Experimental Metastasis describes “a new Neu” — a syngeneic model of spontaneously metastatic HER2‑positive breast cancer. This model offers us the ability to ask fascinating questions of the metastatic TME… watch this space for more to come soon! This was a large collaboration led by the lab of Evanthia Roussos Torres working closely with Jesse and Yingtong in our lab, plus contributions from others labs at Johns Hopkins.

Riddhee award a USC SURF fellowship

Congratulations to Riddhee Mehta who has been awarded a USC SURF fellowship to continue her research in the lab over the summer. Riddhee is a QBIO student working towards a Masters degree in Quantitative and Computational Biology while working in the lab on a project that studies the dynamics of EMT, co-mentored by MeiLu. Riddhee’s research has already led to new insights into EMT intermediate state dynamics.

Out now: Gastrulation-stage gene Nipbl+/- expression mis-directs cell fates

Collaborative paper on which we contributed, led by the labs of Anne Calof and Arthur Lander at UC Irvine is out now in Science Advances (UCI news article here). We discovered a key role for heterogenous Nipbl+/- expression in mouse embryo fate mis-direction, mediated in part by Nanog overexpression. Use of CellRank for single-cell fate mapping helped to reveal the mis-direction of these gastrulation-stage cell fates. This collaboration was supported by an opportunity award grant to first-author Stephenson Chea at UCI and Jesse in the MacLean lab.

Stem cells in the classroom

As a part of our ongoing effort to translate our research modeling stem cell biology into curricula appropriate from early K-12 education, Adam visited 3rd grade at Weemes Elementary School on Monday to discuss how math and computers help us to learn about stem cells. We also had a lot of fun playing stem cell superhero. (You can try the game out here)

Paper out now: Single-cell multiomics of kidney dimorphism

Our paper investigating the origins of sexual dimorphism in the mouse kidney is out now in Developmental Cell. In this collaboration led by the McMahon lab, together with Pachter and Kim labs, we discovered that regulation mediated largely through Androgen receptor (AR) controls the dimorphism of the mouse kidney. This was made possible via bulk RNA-seq temporal data coupled with single-cell multiomics integrated through computational analyses.