In new work led by Anupam we reveal that choice of network logic in ODE modeling of gene regulatory networks plays an underappreciated and oversized role in determining cell fate outcomes. In application to tristable EMT landscapes, we show that it is critical to consider the choice of logic when constructing models.
By mapping out transition paths dictated by logic we provide methods with which to infer the logic used by gene circuits in live cells undergoing EMT through simple perturbation experiments. Read the paper on bioRxiv.