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Out now: Gastrulation-stage gene Nipbl+/- expression mis-directs cell fates

Collaborative paper on which we contributed, led by the labs of Anne Calof and Arthur Lander at UC Irvine is out now in Science Advances (UCI news article here). We discovered a key role for heterogenous Nipbl+/- expression in mouse embryo fate mis-direction, mediated in part by Nanog overexpression. Use of CellRank for single-cell fate mapping helped to reveal the mis-direction of these gastrulation-stage cell fates. This collaboration was supported by an opportunity award grant to first-author Stephenson Chea at UCI and Jesse in the MacLean lab.

Stem cells in the classroom

As a part of our ongoing effort to translate our research modeling stem cell biology into curricula appropriate from early K-12 education, Adam visited 3rd grade at Weemes Elementary School on Monday to discuss how math and computers help us to learn about stem cells. We also had a lot of fun playing stem cell superhero. (You can try the game out here)

Paper out now: Single-cell multiomics of kidney dimorphism

Our paper investigating the origins of sexual dimorphism in the mouse kidney is out now in Developmental Cell. In this collaboration led by the McMahon lab, together with Pachter and Kim labs, we discovered that regulation mediated largely through Androgen receptor (AR) controls the dimorphism of the mouse kidney. This was made possible via bulk RNA-seq temporal data coupled with single-cell multiomics integrated through computational analyses.

New preprint: Regulatory networks controlling sex differences in the kidney

Ivy’s paper is out now! In a large collaboration led by the McMahon lab together with our lab & and the labs of Lior Pachter & Junhyong Kim we investigated the origins of sex differences in the mammalian kidney. Did you know that male and female kidneys have highly diverged gene expression programs in proximal tubule cells?! Through time-course RNA-seq coupled with joint multiomics (assaying scRNA-seq + scATAC-seq) of WT and AR-ko kidneys we discovered how Androgen receptor controls the sex dimorphism of cell fates in the kidney.