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Paper out now: age-dependent effects of Igf2bp2 on HSCs

Our paper: Age-dependent effects of Igf2bp2 on gene regulation, function, and aging of hematopoietic stem cells in mice, is out now in Blood. In this work, Megan led the computational analyses of bulk and single-cell RNA-sequencing data of HSCs to study the role of RNA-binding protein Igf2bp2. We discovered a complex role for Igf2bp2 in aging-associated HSC phenotypes, whereby it positively regulates oxidative metabolism in young mice, yet its loss may ameliorate aging-related deteriorations in hematopoietic function.

Ivy, Jesse, Xiaojun awarded IOA

Ivy, Jesse, and Xiaojun were awarded an opportunity award grant together with Stephenson Chea at UC Irvine. It will study cell fate decisions in a model of Cornelia de Lange Syndrome. This proposal grew out of the annual symposium held at the UC Irvine NSF-Simons Center, congratulations all!

QCB departmental retreat

We attended the 2021 QCB departmental retreat in Ventura, CA. It was great to cautiously gather again in person for talks and tacos under the pelicans fishing for lunch. In envy of the lab t-shirts of our neighbors (Edge lab), Adam was surprised by these great hand-drawn creations.

Welcome new postdocs Ivy and Jesse!

Welcome to Ivy and Jesse who join the lab as postdoctoral researchers.

Ivy recently completed her PhD at the University of Oxford, studying the interplay between inherited and somatic genetic variants in cancer.

Jesse recently completed his PhD at the University of California, Irvine, modeling viral dynamics using various approaches including hybrid stochastic-deterministic methods.