Anupam led a project on the role of logic in modeling gene regulatory network (GRN) dynamics. Through a detailed investigation into the role of logic in GRN models of EMT and developmental fate decisions, we discovered that choice of logic (AND vs OR) profoundly impacts cell fate. We go on to highlight — beyond the caution that must be exercised in choice of logic — that through experimental design it is possible to infer the logic of GRNs in vivo. Read the paper in Development.
Also, thanks to an initiative from the Company of Biologists, a pedunculate oak tree accompanies our paper in the Forest of Biologists.
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