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Out now: Gastrulation-stage gene Nipbl+/- expression mis-directs cell fates

Collaborative paper on which we contributed, led by the labs of Anne Calof and Arthur Lander at UC Irvine is out now in Science Advances (UCI news article here). We discovered a key role for heterogenous Nipbl+/- expression in mouse embryo fate mis-direction, mediated in part by Nanog overexpression. Use of CellRank for single-cell fate mapping helped to reveal the mis-direction of these gastrulation-stage cell fates. This collaboration was supported by an opportunity award grant to first-author Stephenson Chea at UCI and Jesse in the MacLean lab.