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Paper out now: age-dependent effects of Igf2bp2 on HSCs

Our paper: Age-dependent effects of Igf2bp2 on gene regulation, function, and aging of hematopoietic stem cells in mice, is out now in Blood. In this work, Megan led the computational analyses of bulk and single-cell RNA-sequencing data of HSCs to study the role of RNA-binding protein Igf2bp2. We discovered a complex role for Igf2bp2 in aging-associated HSC phenotypes, whereby it positively regulates oxidative metabolism in young mice, yet its loss may ameliorate aging-related deteriorations in hematopoietic function.