Adam and Jonathan attended ECMTB / SMB 2026 in Graz, Austria. Jonathan presented his recent work on control of early hematopoietic stem cell fate decisions. In his new model of stem cell exit-from-quiescence a two-gene circuit permits up to four coexisting stable steady states (tetrastability), including two intermediate states. Thus predicting that stem-to-multipotent differentiation proceeds through a series of fine-scale transitions rather than a single commitment event. Read the preprint here.
