Two new preprints are out this month from our lab in collaboration with the Evanthia Roussos Torres lab at USC Keck. In the first, Yingtong developed a new method, iterative logistic regression: iLR, to identify subtle effects in single-cell gene expression datasets. This led to the discovery of myeloid cell differentiation pathways as a target of entinostat, an epigenetic modulator. Read the preprint here.
In the second, Jesse co-led a large cancer systems immunology project with Edgar Gonzalez that integrated preclinical and clinical data with mathematical models to reveal how combination therapies act on tumor-immune interactions during breast cancer metastasis. We discovered an essential role for myeloid-derived suppressor cell and tumor-associated macrophage interactions with T cells, as well as B cell activation, in mediating the effects of therapy. Read the preprint here.