Our new preprint led by Jesse with input from Xiaojun and the Roussos Torres lab is out now: Beyond RECIST: mathematical modeling and Bayesian inference reveal the importance of immune parameters in metastatic breast cancer.
In which we present a modeling+inference framework to extrapolate beyond small, heterogeneous phase 1 cohorts and personalize tumor-immune models of response to triple combination therapy. We discover that control only of the immune suppressive parameters and not of the cytotoxic parameters is necessary to explain response. Read the paper here.